Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report

Tokiko Abe; Koji Yamashita; Kazufumi Kikuchi; Eriko Hatai; Fumihiko Fujii; Pin Fee Chong; Yasunari Sakai; Hirotomo Saitsu; Ken Inoue; Osamu Togao; Kousei Ishigami

doi:10.1177/19714009231224419

Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report

Tokiko Abe, Koji Yamashita, Kazufumi Kikuchi, Eriko Hatai, Fumihiko Fujii, Pin Fee Chong, Yasunari Sakai, Hirotomo Saitsu, Ken Inoue, Osamu Togao, Kousei Ishigami

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a “sheep sign,” which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the “sheep sign” on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.

Original language	English
Pages (from-to)	758-760
Number of pages	3
Journal	Neuroradiology Journal
Volume	37
Issue number	6
DOIs	https://doi.org/10.1177/19714009231224419
Publication status	Published - Dec 2024

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Clinical Neurology

Access to Document

10.1177/19714009231224419

Cite this

@article{4b5d1a3a674949ceb309ed809b573e92,

title = "Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report",

abstract = "Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a “sheep sign,” which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the “sheep sign” on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.",

keywords = "Hypomyelination, diffusion magnetic resonance imaging, magnetic resonance imaging",

author = "Tokiko Abe and Koji Yamashita and Kazufumi Kikuchi and Eriko Hatai and Fumihiko Fujii and Chong, {Pin Fee} and Yasunari Sakai and Hirotomo Saitsu and Ken Inoue and Osamu Togao and Kousei Ishigami",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2024",

month = dec,

doi = "10.1177/19714009231224419",

language = "English",

volume = "37",

pages = "758--760",

journal = "Neuroradiology Journal",

issn = "1971-4009",

publisher = "SAGE Publications Inc.",

number = "6",

}

TY - JOUR

T1 - Diagnostic MR imaging features of hypomyelination of early myelinating structures

T2 - A case report

AU - Abe, Tokiko

AU - Yamashita, Koji

AU - Kikuchi, Kazufumi

AU - Hatai, Eriko

AU - Fujii, Fumihiko

AU - Chong, Pin Fee

AU - Sakai, Yasunari

AU - Saitsu, Hirotomo

AU - Inoue, Ken

AU - Togao, Osamu

AU - Ishigami, Kousei

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024/12

Y1 - 2024/12

N2 - Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a “sheep sign,” which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the “sheep sign” on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.

AB - Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a “sheep sign,” which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the “sheep sign” on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.

KW - Hypomyelination

KW - diffusion magnetic resonance imaging

KW - magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85180838784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85180838784&partnerID=8YFLogxK

U2 - 10.1177/19714009231224419

DO - 10.1177/19714009231224419

M3 - Article

C2 - 38146229

AN - SCOPUS:85180838784

SN - 1971-4009

VL - 37

SP - 758

EP - 760

JO - Neuroradiology Journal

JF - Neuroradiology Journal

IS - 6

ER -

Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this