Diagnosis of Zollinger-Ellison syndrome: Increasingly difficult

Tetsuhide Ito, Guillaume Cadiot, Robert T. Jensen

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)


In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management.

Original languageEnglish
Pages (from-to)5495-5503
Number of pages9
JournalWorld Journal of Gastroenterology
Issue number39
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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