Development of polyion complex vesicles (PICsomes) from block copolymers for biomedical applications

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


Polyion complex (PIC) formation is one of the most powerful techniques for obtaining molecular self-assemblies in aqueous media. The simple preparation process based on multiple electrostatic interactions is quite attractive for material syntheses, as well as biomedical applications. Therefore, it is desirable to control PIC architectures at the nanoscale in order to expand the scope of PIC materials. In this review article, recent progress on PIC vesicles (PICsomes) is summarized. PICsomes were first developed by my research group, and we recently succeeded in controlling the sizes and structural uniformity of the vesicles. Furthermore, the characteristic dynamic nature of PICs was revealed: PICs were found to exhibit reversible association/dissociation and structural transformation. We demonstrated that crosslinking the PIC layers of PICsomes is a powerful method for tuning properties such as stability and permeability. Finally, the potential utility of PICsomes for drug delivery nanocarriers was examined, and their future biomedical application is discussed.

Original languageEnglish
Pages (from-to)892-897
Number of pages6
JournalPolymer Journal
Issue number9
Publication statusPublished - Sept 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry


Dive into the research topics of 'Development of polyion complex vesicles (PICsomes) from block copolymers for biomedical applications'. Together they form a unique fingerprint.

Cite this