TY - JOUR
T1 - Development of novel functional molecules targeting DNA and RNA
AU - Sasaki, Shigeki
N1 - Funding Information:
at the Graduate School of Pharmaceutical Sciences, Kyushu University. I would like to thank past and present staff and students of this laboratory: Professors F. Nagatsugi, O. Nakagawa, Y. Taniguchi, Y. Fuchi and Y. Abe, as well as the many participating students whose names are not listed in this paper. I would also like to express my sincere appreciation of the late Professor Emeritus K. Koga of the University of Tokyo, and Professor Emeritus M. Maeda of Kyushu University for their encouragement in this research field. This study has been financially supported by the Japan Society for the Promotion of Science (JSPS) (Grant-in-Aid for Scientific Research (B), (A), (S) and for Challenging Exploratory Research), the Uehara Memorial Foundation, and the Astellas Foundation for Research on Metabolic Disorders. I also gratefully acknowledge the financial support and collaboration of Professor Emeritus K. Kataoka for his CREST project (Japan Science and Technology Agency (JST)).
Publisher Copyright:
© 2019 The Pharmaceutical Society of Japan
PY - 2019
Y1 - 2019
N2 - Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.
AB - Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.
UR - http://www.scopus.com/inward/record.url?scp=85067099036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067099036&partnerID=8YFLogxK
U2 - 10.1248/cpb.c19-00169
DO - 10.1248/cpb.c19-00169
M3 - Review article
C2 - 31155555
AN - SCOPUS:85067099036
SN - 0009-2363
VL - 67
SP - 505
EP - 518
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 6
ER -