TY - JOUR
T1 - Development of novel collagen scaffolds with different bioceramic particles for bone tissue engineering
AU - Arahira, Takaaki
AU - Todo, Mitsugu
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number 18K17093 .
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Porous scaffolds comprising natural polymers and bioceramic particles have recently been used in tissue engineering. Collagen is one such natural polymer providing favorable biological conditions; for example, it stimulates the generation and differentiation of cells as an extracellular matrix. α-Tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP) have also been widely used in bone tissue engineering owing to their favorable osteoconductivity, cellular adhesion, accelerated differentiation, and mechanical properties. In the present study, collagen scaffolds with different bioceramic particles were successfully fabricated by varying the ratio of α-TCP and β-TCP particles. Our results indicate that material properties, such as compressive modulus, swelling behavior, and porosity, can be controlled by varying the ratio of α-TCP and β-TCP particles.
AB - Porous scaffolds comprising natural polymers and bioceramic particles have recently been used in tissue engineering. Collagen is one such natural polymer providing favorable biological conditions; for example, it stimulates the generation and differentiation of cells as an extracellular matrix. α-Tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP) have also been widely used in bone tissue engineering owing to their favorable osteoconductivity, cellular adhesion, accelerated differentiation, and mechanical properties. In the present study, collagen scaffolds with different bioceramic particles were successfully fabricated by varying the ratio of α-TCP and β-TCP particles. Our results indicate that material properties, such as compressive modulus, swelling behavior, and porosity, can be controlled by varying the ratio of α-TCP and β-TCP particles.
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U2 - 10.1016/j.coco.2019.08.012
DO - 10.1016/j.coco.2019.08.012
M3 - Article
AN - SCOPUS:85071401999
SN - 2452-2139
VL - 16
SP - 30
EP - 32
JO - Composites Communications
JF - Composites Communications
ER -