Abstract
The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.
| Original language | English |
|---|---|
| Pages (from-to) | 1078-1087 |
| Number of pages | 10 |
| Journal | Molecules |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2015 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry
Fingerprint
Dive into the research topics of 'Development of new 1,3-diazaphenoxazine derivatives (thiog-grasp) to covalently capture 8-thioguanosine'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS