Development of liquid phase immunoassay system using magnetic nanoparticles

Hiroyuki Kuma, Akira Tsukamoto, Kazuo Saitoh, Yoshinori Sugiura, Kohji Yoshinaga, Keiji Enpuku, Naotaka Hamasaki

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Biological immunoassay is a major detection system of biological materials from patient samples. Our group has been developing a highly sensitive immunoassay system using magnetic nanoparticles made from Fe3O4. Since unbound magnetic markers randomly move in solvent due to Brownian motion, there is no magnetic signal from unbound magnetic markers; therefore, the separation of bound from unbound markers (B/F separation) is not required. This advantage means that the detection time is greatly decreased in comparison with a normal method using fluorescent/enzyme reagent. In this paper, we describe the configuration of the developed system and demonstrate the performance of the detection of magnetic nanoparticles.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalRinsho byori. The Japanese journal of clinical pathology
Issue number4
Publication statusPublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • General Medicine


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