Explosive molecules that leak out of a landmine may have extremely low concentrations in soil or air. This chapter aims at the development of a highly sensitive biosensor to detect explosive molecules for landmine detection. A highly sensitive surface plasmon resonance-based immunosensor for detection of trisenitrophenol (TNP) functioning with indirect competitive method and displacement method was developed. The sensor detected TNP with the sensitivity of ppb level. In future, monoclonal antibodies to TNT and 2,4-dinitrotoluene (DNT) and a high-performance sampling system will be developed for a landmine detection system. Then one is going to try to detect TNT and DNT using the developed methods with the sampling system and antibodies.
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