Development of Highly Sensitive Biosensor for Explosive Substances

T. Onodera; D. Ravi Shankaran; R. Harada; N. Miura; T. Sakai; K. Matsumoto; J. Liang; K. Toko; T. Imato

doi:10.1016/B978-044451813-2/50023-3

Development of Highly Sensitive Biosensor for Explosive Substances

T. Onodera, D. Ravi Shankaran, R. Harada, N. Miura, T. Sakai, K. Matsumoto, J. Liang, K. Toko, T. Imato

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Abstract

Explosive molecules that leak out of a landmine may have extremely low concentrations in soil or air. This chapter aims at the development of a highly sensitive biosensor to detect explosive molecules for landmine detection. A highly sensitive surface plasmon resonance-based immunosensor for detection of trisenitrophenol (TNP) functioning with indirect competitive method and displacement method was developed. The sensor detected TNP with the sensitivity of ppb level. In future, monoclonal antibodies to TNT and 2,4-dinitrotoluene (DNT) and a high-performance sampling system will be developed for a landmine detection system. Then one is going to try to detect TNT and DNT using the developed methods with the sampling system and antibodies.

Original language	English
Title of host publication	Systems and Human Science - For Safety, Security and Dependability
Publisher	Elsevier
Pages	287-295
Number of pages	9
ISBN (Print)	9780444518132
DOIs	https://doi.org/10.1016/B978-044451813-2/50023-3
Publication status	Published - 2005

All Science Journal Classification (ASJC) codes

Engineering(all)

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10.1016/B978-044451813-2/50023-3

Cite this

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title = "Development of Highly Sensitive Biosensor for Explosive Substances",

abstract = "Explosive molecules that leak out of a landmine may have extremely low concentrations in soil or air. This chapter aims at the development of a highly sensitive biosensor to detect explosive molecules for landmine detection. A highly sensitive surface plasmon resonance-based immunosensor for detection of trisenitrophenol (TNP) functioning with indirect competitive method and displacement method was developed. The sensor detected TNP with the sensitivity of ppb level. In future, monoclonal antibodies to TNT and 2,4-dinitrotoluene (DNT) and a high-performance sampling system will be developed for a landmine detection system. Then one is going to try to detect TNT and DNT using the developed methods with the sampling system and antibodies.",

author = "T. Onodera and Shankaran, {D. Ravi} and R. Harada and N. Miura and T. Sakai and K. Matsumoto and J. Liang and K. Toko and T. Imato",

note = "Funding Information: This work has been supported by Japan Science and Technology Agency (JST).",

year = "2005",

doi = "10.1016/B978-044451813-2/50023-3",

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TY - CHAP

T1 - Development of Highly Sensitive Biosensor for Explosive Substances

AU - Onodera, T.

AU - Shankaran, D. Ravi

AU - Harada, R.

AU - Miura, N.

AU - Sakai, T.

AU - Matsumoto, K.

AU - Liang, J.

AU - Toko, K.

AU - Imato, T.

N1 - Funding Information: This work has been supported by Japan Science and Technology Agency (JST).

PY - 2005

Y1 - 2005

N2 - Explosive molecules that leak out of a landmine may have extremely low concentrations in soil or air. This chapter aims at the development of a highly sensitive biosensor to detect explosive molecules for landmine detection. A highly sensitive surface plasmon resonance-based immunosensor for detection of trisenitrophenol (TNP) functioning with indirect competitive method and displacement method was developed. The sensor detected TNP with the sensitivity of ppb level. In future, monoclonal antibodies to TNT and 2,4-dinitrotoluene (DNT) and a high-performance sampling system will be developed for a landmine detection system. Then one is going to try to detect TNT and DNT using the developed methods with the sampling system and antibodies.

AB - Explosive molecules that leak out of a landmine may have extremely low concentrations in soil or air. This chapter aims at the development of a highly sensitive biosensor to detect explosive molecules for landmine detection. A highly sensitive surface plasmon resonance-based immunosensor for detection of trisenitrophenol (TNP) functioning with indirect competitive method and displacement method was developed. The sensor detected TNP with the sensitivity of ppb level. In future, monoclonal antibodies to TNT and 2,4-dinitrotoluene (DNT) and a high-performance sampling system will be developed for a landmine detection system. Then one is going to try to detect TNT and DNT using the developed methods with the sampling system and antibodies.

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M3 - Chapter

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SN - 9780444518132

SP - 287

EP - 295

BT - Systems and Human Science - For Safety, Security and Dependability

PB - Elsevier

ER -

Development of Highly Sensitive Biosensor for Explosive Substances

Abstract

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