[Development of hemostatic sealant for arterial anastomosis; clinical application].

Shigeki Morita, Takehisa Matsuda, Masataka Eto, Shinichiro Oda, Ryuji Tominaga

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


For the purpose of examining the clinical applicability of a newly developed surgical sealant, animal experiments were performed, and clinical trial was followed. In animal experiments, several animal models, including carotid artery anastomosis model and coronary artery bypass grafting model were undertaken. In each model, complete hemostasis of the anastomoses using four simple interrupted sutures, was obtained. In addition, elastomeric property of the sealant prevented thinning of the arterial wall. The clinical trial performed in patients with thoracic aortic surgery showed significantly better hemostasis even under heparinized condition. Based on these excellent results, clinical usage of the sealant was approved.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalKyobu geka. The Japanese journal of thoracic surgery
Issue number5
Publication statusPublished - May 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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