Development of carbonate apatite as artificial bone substitute

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Carbonate apatite (CO3Ap) that contains 6-9 wt% carbonate in apatitic structure is the composition of human bone. Unfortunately, CO3Ap cannot be sintered due to the presence of CO3. CO3Ap block was found to be fabricated based on a compositional transformation though dissolution-precipitation reaction using a precursor such as calcite block. CO3Ap block thus fabricated up-regulate the differentiation of osteoblastic cells and resorbed by the osteoclasts. As results of these response to cells, CO3Ap block demonstrate much better osteoconductivity than hydroxyapatite [HAp: Ca10(PO4)6(OH)2)] which is currently used artificial bone substitute. Also, CO3Ap block was found to be replace to new bone similar to autograft even though HAp would not replace to bone. Clinical trial of CO3Ap is now in progress, and CO3Ap will be available for its clinical use next year.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalJapanese Magazine of Mineralogical and Petrological Sciences
Issue number1
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Geochemistry and Petrology
  • Economic Geology


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