Development of Calcium Phosphate Cement for Rapid Crystallization to Apatite

Masayuki Kon, Youji Miyamoto, Kenzo Asaoka, Kunio Ishikawa, Hae Hyoung Lee

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The purpose of this study was to develop an α-tricalcium phosphate (α-TCP) cement which transforms to hydroxyapatite (HAP) in a relatively short period. We used calcium and phosphate solutions as the liquid phase for the α-TCP cement. The α-TCP powder was first mixed with CaCl2 solution, and then mixed with Na2HPO4 or Na2HPO4, solution for a total powder liquid ratio of 1.8. The setting time became shorter with the increase in the concentration of calcium and phosphate solutions, reaching 5 min, whereas the setting time was longer than 30 min when distilled water was used as the liquid phase. X-ray diffraction analysis revealed that the cement was mostly transformed to HAP within 24 h when kept in an incubator. We concluded that α-TCP should be mixed with calcium and phosphate solutions since this results in a moderate setting time and fast transformation to HAP even if the method of mixing becomes a little complex.

Original languageEnglish
Pages (from-to)223-232
Number of pages10
Journaldental materials journal
Issue number4
Publication statusPublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)


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