Development of a biochemical switching device: Mathematical model

Masahiro Okamoto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


There are many examples of enzymes that share substrates or cofactors in a cyclic manner. Techniques have been developed that use cyclic enzyme systems to assay quantitatively small amounts of biochemical substances (cofactor, substrate), however, only a few studies of the control of these systems have been published. The author previously showed with computer simulations that cyclic enzyme systems have the reliability of ON-OFF types of operation (McCulloch-Pitts' neuronic equation) and the applicability for a switching circuit in a biocomputer. The switching time was inevitably determined in accordance with the difference in amount between two inputs of the system. A unique switching mechanism of cyclic enzyme systems (basic switching element) and the effects of excitatory stimuli on switching properties of the integrated biochemical switching system are demonstrated.

Original languageEnglish
Pages (from-to)917-933
Number of pages17
JournalBiomedica Biochimica Acta
Issue number8-9
Publication statusPublished - Dec 1 1990

All Science Journal Classification (ASJC) codes

  • Biochemistry


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