TY - GEN
T1 - Development and characterization of porous calcium phosphate cement using α-tricalcium phosphate bead
AU - Kien, Pham Trung
AU - Kanji, Tsuru
AU - Ishikawa, Kunio
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Interconnected set porous-calcium phosphate cement (set porous-CPC), which has fully interconnected pores could be an ideal bone substitute. In this study, set porous- CPC consisting of α-tricalcium phosphate (α-TCP) beads and acidic calcium phosphate solution was developed and its basic setting reaction was studied. When α-TCP beads were exposed to the acidic calcium phosphate solution, brushite (CaHPO4 ·2H2O) was formed on the surface of the α-TCP beads. The formed brushite crystals interlocked with each other, resulting in a setting reaction of α-TCP microspheres within 10 min at 37°C. As a result of this setting reaction, a fullyinterconnected calcium phosphate macroporous structure was obtained. The set porous-CPC were immersed into simulated body fluid (SBF) at 37oC for different immersion time, The result clearly showed that brushite surface layer transformed to apatite layer after 3 days immersion into SBF solution by dissolution-precipitation reaction. Since apatite layer show excellent tissue response, the set porous-CPC would be a promising biomaterial used as artificial bone substitutes, and as the scaffold for tissue engineering.
AB - Interconnected set porous-calcium phosphate cement (set porous-CPC), which has fully interconnected pores could be an ideal bone substitute. In this study, set porous- CPC consisting of α-tricalcium phosphate (α-TCP) beads and acidic calcium phosphate solution was developed and its basic setting reaction was studied. When α-TCP beads were exposed to the acidic calcium phosphate solution, brushite (CaHPO4 ·2H2O) was formed on the surface of the α-TCP beads. The formed brushite crystals interlocked with each other, resulting in a setting reaction of α-TCP microspheres within 10 min at 37°C. As a result of this setting reaction, a fullyinterconnected calcium phosphate macroporous structure was obtained. The set porous-CPC were immersed into simulated body fluid (SBF) at 37oC for different immersion time, The result clearly showed that brushite surface layer transformed to apatite layer after 3 days immersion into SBF solution by dissolution-precipitation reaction. Since apatite layer show excellent tissue response, the set porous-CPC would be a promising biomaterial used as artificial bone substitutes, and as the scaffold for tissue engineering.
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U2 - 10.1007/978-3-319-11776-8_125
DO - 10.1007/978-3-319-11776-8_125
M3 - Conference contribution
AN - SCOPUS:84928234901
T3 - IFMBE Proceedings
SP - 507
EP - 510
BT - 5th International Conference on Biomedical Engineering in Vietnam
A2 - Toi, Vo Van
A2 - Phuong, Tran Ha Lien
PB - Springer Verlag
T2 - 5th International Conference on the Development of Biomedical Engineering, 2014
Y2 - 16 June 2014 through 18 June 2014
ER -