TY - JOUR
T1 - Deubiquitinases in Cancers
T2 - Aspects of Proliferation, Metastasis, and Apoptosis
AU - LIU, Jiaqi
AU - LEUNG, Chi Tim
AU - LIANG, Luyun
AU - WANG, Yuqin
AU - CHEN, Jian
AU - LAI, Keng Po
AU - TSE, William Ka Fai
N1 - Funding Information:
The researches in JC and KPL groups are supported by the National Natural Science Foundation of China (No. 81973574, 82060736, 82160282), National Natural Science Foundation of Guangxi (No. 2019GXNSFFA245001, 2018GXNSFAA281334). The biomedical research in WKFT group are supported by the Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (22K07025); and the National Institute of Basic Biology Collaborative Research Program, Japan (21-213; 22NIBB322).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/7
Y1 - 2022/7
N2 - Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.
AB - Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.
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U2 - 10.3390/cancers14143547
DO - 10.3390/cancers14143547
M3 - Review article
AN - SCOPUS:85136400791
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 14
M1 - 3547
ER -
