Detection of toxic protein by saccharide-modified gold nanoparticles

Ken Oya, Yoshiko Miura, Yoshihiro Nishida, Kazukiyo Kobayashi

Research output: Contribution to conferencePaperpeer-review


We have investigated the functionality of saccharide-modified gold nanoparticles and apply for detection of toxic protein such as Shiga toxin and RCA120. Lactose, Gb2 and Gb3 derivatives were synthesized by thioglycosylation method. Gold nanoparticles have been prepared by Brust-Schiffrin method and modified the surface with saccharide derivatives by thiol exchange reaction. Although the lactose-modified gold nanoparticles dispersed stably in aqueous solution, it showed rapid and specific aggregation by the addition of RCA120.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sept 20 2005Sept 22 2005


Other54th SPSJ Symposium on Macromolecules

All Science Journal Classification (ASJC) codes

  • General Engineering


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