Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients

Tomonori Minagawa; Kazuya Mizuno; Seiko Hirano; Misako Asano; Akihiko Numata; Masashi Kohanawa; Akio Nakane; Kei Hachimori; Sigenori Tamagawa; Masayoshi Negishi; Shojiro Yamazaki; Yu ichiro Satoh

doi:10.1016/0024-3205(89)90147-1

Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients

Tomonori Minagawa, Kazuya Mizuno, Seiko Hirano, Misako Asano, Akihiko Numata, Masashi Kohanawa, Akio Nakane, Kei Hachimori, Sigenori Tamagawa, Masayoshi Negishi, Shojiro Yamazaki, Yu ichiro Satoh

Research output: Contribution to journal › Article › peer-review

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Abstract

We have examined human interferon beta-1 (HuIFN-β1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzymelinked immunosorbent assay system (ELISA). High levels of HuIFN-β1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infected patients, especially of asymptomatic carriers. The serum level of HuIFN-β1 may be a good indicator of HIV-I infection and of other immunological disorders.

Original language	English
Pages (from-to)	iii-vii
Journal	Life Sciences
Volume	45
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(89)90147-1
Publication status	Published - 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/0024-3205(89)90147-1

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title = "Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients",

abstract = "We have examined human interferon beta-1 (HuIFN-β1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzymelinked immunosorbent assay system (ELISA). High levels of HuIFN-β1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infected patients, especially of asymptomatic carriers. The serum level of HuIFN-β1 may be a good indicator of HIV-I infection and of other immunological disorders.",

author = "Tomonori Minagawa and Kazuya Mizuno and Seiko Hirano and Misako Asano and Akihiko Numata and Masashi Kohanawa and Akio Nakane and Kei Hachimori and Sigenori Tamagawa and Masayoshi Negishi and Shojiro Yamazaki and Satoh, {Yu ichiro}",

note = "Funding Information: This work was supported by a grant Science Foundation, Tokyo, Japan.",

year = "1989",

doi = "10.1016/0024-3205(89)90147-1",

language = "English",

volume = "45",

pages = "iii--vii",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients

AU - Minagawa, Tomonori

AU - Mizuno, Kazuya

AU - Hirano, Seiko

AU - Asano, Misako

AU - Numata, Akihiko

AU - Kohanawa, Masashi

AU - Nakane, Akio

AU - Hachimori, Kei

AU - Tamagawa, Sigenori

AU - Negishi, Masayoshi

AU - Yamazaki, Shojiro

AU - Satoh, Yu ichiro

N1 - Funding Information: This work was supported by a grant Science Foundation, Tokyo, Japan.

PY - 1989

Y1 - 1989

N2 - We have examined human interferon beta-1 (HuIFN-β1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzymelinked immunosorbent assay system (ELISA). High levels of HuIFN-β1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infected patients, especially of asymptomatic carriers. The serum level of HuIFN-β1 may be a good indicator of HIV-I infection and of other immunological disorders.

AB - We have examined human interferon beta-1 (HuIFN-β1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzymelinked immunosorbent assay system (ELISA). High levels of HuIFN-β1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infected patients, especially of asymptomatic carriers. The serum level of HuIFN-β1 may be a good indicator of HIV-I infection and of other immunological disorders.

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U2 - 10.1016/0024-3205(89)90147-1

DO - 10.1016/0024-3205(89)90147-1

M3 - Article

C2 - 2796591

AN - SCOPUS:0024408491

SN - 0024-3205

VL - 45

SP - iii-vii

JO - Life Sciences

JF - Life Sciences

IS - 11

ER -

Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients

Abstract

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