TY - JOUR
T1 - Detection of ammonia in human breath using quartz crystal microbalance sensors with functionalized mesoporous SiO2 nanoparticle films
AU - Ogimoto, Yusuke
AU - Selyanchyn, Roman
AU - Takahara, Naoki
AU - Wakamatsu, Shunichi
AU - Lee, Seung Woo
N1 - Funding Information:
This work was supported by MEXT via 2nd Kitakyush Knowledge-based Cluster Project (Regional Innovation Cluster Program (Global Type)). We also thank Mr. Tao Wang for technical assistance with the FTIR measurements.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Quartz crystal microbalance (QCM) sensors with porous films comprising silica nanoparticles and poly(allylamine hydrochloride) (PAH) were fabricated. The films were deposited via an electrostatic self-assembly method, and they exhibited considerable sensitivity to relative humidity. The infusion of poly(acrylic acid) (PAA) into multi-layer porous films (5 or 10 cycles) enabled the construction of a highly sensitive and selective QCM sensor device for the detection of gaseous ammonia. Two types of QCM sensors, with and without PAA, were used as sensors for the simultaneous quantitative detection of humidity and ammonia. A comprehensive Fourier transform infrared (FTIR) investigation of the fabricated films was conducted to elucidate the mechanism of the chemical interaction at the sensor device interface. Preliminary tests were conducted to detect low concentrations of ammonia in human breath, which are of clinical relevance. The results of these tests showed that the sensor can detect ammonia in human breath at pathological levels (greater than 3 ppm).
AB - Quartz crystal microbalance (QCM) sensors with porous films comprising silica nanoparticles and poly(allylamine hydrochloride) (PAH) were fabricated. The films were deposited via an electrostatic self-assembly method, and they exhibited considerable sensitivity to relative humidity. The infusion of poly(acrylic acid) (PAA) into multi-layer porous films (5 or 10 cycles) enabled the construction of a highly sensitive and selective QCM sensor device for the detection of gaseous ammonia. Two types of QCM sensors, with and without PAA, were used as sensors for the simultaneous quantitative detection of humidity and ammonia. A comprehensive Fourier transform infrared (FTIR) investigation of the fabricated films was conducted to elucidate the mechanism of the chemical interaction at the sensor device interface. Preliminary tests were conducted to detect low concentrations of ammonia in human breath, which are of clinical relevance. The results of these tests showed that the sensor can detect ammonia in human breath at pathological levels (greater than 3 ppm).
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U2 - 10.1016/j.snb.2015.03.103
DO - 10.1016/j.snb.2015.03.103
M3 - Article
AN - SCOPUS:84928387397
SN - 0925-4005
VL - 215
SP - 428
EP - 436
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -