TY - JOUR
T1 - Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors
AU - Moriyama, Hideki
AU - Tsukida, Takahiro
AU - Inoue, Yoshimasa
AU - Kondo, Hirosato
AU - Yoshino, Kohichiro
AU - Nishimura, Shin Ichiro
N1 - Funding Information:
The present work was supported by a grant for ‘Research and Development on Glycocluster Control-ling Biomolecules’ from the New Energy and Industrial Technology Development Organization (NEDO).
PY - 2003/8/18
Y1 - 2003/8/18
N2 - In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.
AB - In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.
UR - http://www.scopus.com/inward/record.url?scp=0037811296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037811296&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00531-6
DO - 10.1016/S0960-894X(03)00531-6
M3 - Article
C2 - 12873505
AN - SCOPUS:0037811296
SN - 0960-894X
VL - 13
SP - 2741
EP - 2744
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 16
ER -