TY - JOUR
T1 - Design of highly efficient receptor sites by combination of cyclodextrin units and molecular cavity in TiO2 ultrathin layer
AU - Yang, Do Hyeon
AU - Ju, Myung Jong
AU - Maeda, Aya
AU - Hayashi, Kenshi
AU - Toko, Kiyoshi
AU - Lee, Seung Woo
AU - Kunitake, Toyoki
N1 - Funding Information:
This work was supported by the MEXT via the Kitakyushu Knowledge-based Cluster Project and a Grant-in-Aid for Science Research (No. 17651075) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2006/9/26
Y1 - 2006/9/26
N2 - A highly effective approach was developed for sensitive detection of organic substances in water. In order to achieve high sensitivity and selective detection for aromatic compounds, cyclodextrin (CD) hosts and imprinting effects were combined to fabricate binding sites within TiO2 ultrathin layer. The electrode surface was modified with ultrathin TiO2 gel film containing a 2:1 complex of β-CD and bisphenol A (BPA), and then the BPA moiety was removed by washing. The resulting BPA-imprinted TiO2/β-CD film showed specific and sensitive detection of BPA, as confirmed by quartz crystal microbalance (QCM) and cyclic surface-polarization impedance (cSPI) measurements. The high selectivity for BPA relative to structurally related guest molecules was estimated to be 1.6-3.4 at the guest concentration of 2 × 10-7 M, and was considered to arise from the synergic effect of the binding site.
AB - A highly effective approach was developed for sensitive detection of organic substances in water. In order to achieve high sensitivity and selective detection for aromatic compounds, cyclodextrin (CD) hosts and imprinting effects were combined to fabricate binding sites within TiO2 ultrathin layer. The electrode surface was modified with ultrathin TiO2 gel film containing a 2:1 complex of β-CD and bisphenol A (BPA), and then the BPA moiety was removed by washing. The resulting BPA-imprinted TiO2/β-CD film showed specific and sensitive detection of BPA, as confirmed by quartz crystal microbalance (QCM) and cyclic surface-polarization impedance (cSPI) measurements. The high selectivity for BPA relative to structurally related guest molecules was estimated to be 1.6-3.4 at the guest concentration of 2 × 10-7 M, and was considered to arise from the synergic effect of the binding site.
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U2 - 10.1016/j.bios.2006.06.013
DO - 10.1016/j.bios.2006.06.013
M3 - Article
C2 - 16935485
AN - SCOPUS:33748146441
SN - 0956-5663
VL - 22
SP - 388
EP - 392
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
IS - 3
ER -