Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

Shigeki Sasaki; Shouji Nakashima; Fumi Nagatsugi; Yoshitsugu Tanaka; Masao Hisatome; Minoru Maeda

doi:10.1016/0040-4039(95)02064-0

Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

Shigeki Sasaki, Shouji Nakashima, Fumi Nagatsugi, Yoshitsugu Tanaka, Masao Hisatome, Minoru Maeda

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A new artificial nucleobase (1) was designed for the selective formation of a triple-complex with a cytosine-guanine base pair at the major groove site. It has been proved based on the 1D- and 2D ¹H-NMR spectra that the protected 2′-oxy-1 (7) forms a triplex complex with the GC pair selectively.

Original language	English
Pages (from-to)	9521-9524
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	52
DOIs	https://doi.org/10.1016/0040-4039(95)02064-0
Publication status	Published - Dec 25 1995

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair",

abstract = "A new artificial nucleobase (1) was designed for the selective formation of a triple-complex with a cytosine-guanine base pair at the major groove site. It has been proved based on the 1D- and 2D 1H-NMR spectra that the protected 2′-oxy-1 (7) forms a triplex complex with the GC pair selectively.",

author = "Shigeki Sasaki and Shouji Nakashima and Fumi Nagatsugi and Yoshitsugu Tanaka and Masao Hisatome and Minoru Maeda",

note = "Funding Information: Acknowledgments This study was partmlly supported the Ministry of Education, Science and Culture, Japan.",

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T1 - Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

AU - Sasaki, Shigeki

AU - Nakashima, Shouji

AU - Nagatsugi, Fumi

AU - Tanaka, Yoshitsugu

AU - Hisatome, Masao

AU - Maeda, Minoru

N1 - Funding Information: Acknowledgments This study was partmlly supported the Ministry of Education, Science and Culture, Japan.

PY - 1995/12/25

Y1 - 1995/12/25

N2 - A new artificial nucleobase (1) was designed for the selective formation of a triple-complex with a cytosine-guanine base pair at the major groove site. It has been proved based on the 1D- and 2D 1H-NMR spectra that the protected 2′-oxy-1 (7) forms a triplex complex with the GC pair selectively.

AB - A new artificial nucleobase (1) was designed for the selective formation of a triple-complex with a cytosine-guanine base pair at the major groove site. It has been proved based on the 1D- and 2D 1H-NMR spectra that the protected 2′-oxy-1 (7) forms a triplex complex with the GC pair selectively.

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U2 - 10.1016/0040-4039(95)02064-0

DO - 10.1016/0040-4039(95)02064-0

M3 - Article

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VL - 36

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 52

ER -

Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

Abstract

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