@article{9591c45915924b9f81da36e7a9954ee2,
title = "Design of a Bioinert Interface Using an Amphiphilic Block Copolymer Containing a Bottlebrush Unit of Oligo(oxazoline)",
abstract = "We designed an amphiphilic block copolymer, poly(methyl methacrylate)-block-poly[oligo(2-ethyl-2-oxazoline) methacrylate] (PMMA-b-P[O(Ox)MA]), suitable for bioinert coating. Angular-dependent X-ray photoelectron spectroscopy and neutron reflectivity measurements revealed that the outermost surface of a dried film of PMMA-b-P[O(Ox)MA] was covered with the PMMA block-rich layer. Once the film came into contact with water, the P[O(Ox)MA] bottlebrush block was segregated toward the water interface. This structural rearrangement in the outermost region of the film resulted in the formation of the swollen oligo(oxazoline) layer with excellent bioinertness in terms of the suppression of serum protein adsorption and NIH3T3 fibroblast adhesion.",
author = "Hong, {Jin Hyeok} and Masayasu Totani and Daisuke Kawaguchi and Hiroyasu Masunaga and Yamada, {Norifumi L.} and Hisao Matsuno and Keiji Tanaka",
note = "Funding Information: We are grateful for support from the JST-Mirai Program (Grant JPMJMI18A2, K.T.), JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (JP20H02790, K.T.) and (B) (JP18H02037, H.M.), and for Early-Career Scientists (Grant JP18K16990, M.T.). The SAXS measurements were carried out at the BL03XU of SPring-8 with the approval of the Japan Synchrotron Radiation Research Institute (JASRI; No. 2019A7220). The NR measurements were approved by the Neutron Scattering Program Advisory Committee of IMSS, KEK with Proposal Nos. 2018B0287, 2019A0255, 2019B0269, 2019B0365, 2020A0272, and 2017L2501. We thank Mr. Junichiro Koike and Mr. Yuji Tamura from DIC Corp. for their fruitful discussions, especially concerning the SAXS analysis. Publisher Copyright: {\textcopyright} ",
year = "2020",
month = nov,
day = "16",
doi = "10.1021/acsabm.0c01118",
language = "English",
volume = "3",
pages = "7363--7368",
journal = "ACS Applied Bio Materials",
issn = "2576-6422",
publisher = "American Chemical Society",
number = "11",
}