TY - JOUR
T1 - Design and synthesis of the novel cross-linking reagents triggered by the triple helix formation.
AU - Nagatsugi, F.
AU - Usui, D.
AU - Kawasaki, T.
AU - Maeda, M.
AU - Sasaki, S.
PY - 2000
Y1 - 2000
N2 - In our attempt to new nucleobase analogs capable of interstrand cross-linking, we developed 2-amino-6-vinyl purine analog (1). The oligonucleotides incorporating 1 showed efficient interstrand cross-linking with selectivity toward cytidine at a target site. In this paper, we describe the design of the new cross-linking reagents (2) bearing 2-amino-6-vinyl purine motif, and triplex-directed alkylation with 2 to double-stranded DNA.
AB - In our attempt to new nucleobase analogs capable of interstrand cross-linking, we developed 2-amino-6-vinyl purine analog (1). The oligonucleotides incorporating 1 showed efficient interstrand cross-linking with selectivity toward cytidine at a target site. In this paper, we describe the design of the new cross-linking reagents (2) bearing 2-amino-6-vinyl purine motif, and triplex-directed alkylation with 2 to double-stranded DNA.
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U2 - 10.1093/nass/44.1.39
DO - 10.1093/nass/44.1.39
M3 - Article
C2 - 12903257
AN - SCOPUS:0141447383
SN - 0261-3166
SP - 39
EP - 40
JO - Nucleic acids symposium series
JF - Nucleic acids symposium series
IS - 44
ER -