Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin

Minoru Yamamoto; Shoji Ikeda; Hirosato Kondo; Shintaro Inoue

doi:10.1016/S0960-894X(01)00755-7

Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin

Minoru Yamamoto, Shoji Ikeda, Hirosato Kondo, Shintaro Inoue

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(01)00755-7
Publication status	Published - Feb 11 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00755-7

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abstract = "The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).",

author = "Minoru Yamamoto and Shoji Ikeda and Hirosato Kondo and Shintaro Inoue",

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AU - Yamamoto, Minoru

AU - Ikeda, Shoji

AU - Kondo, Hirosato

AU - Inoue, Shintaro

PY - 2002/2/11

Y1 - 2002/2/11

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AN - SCOPUS:0037059929

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 3

ER -

Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin

Abstract

All Science Journal Classification (ASJC) codes

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