Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

Tsuyoshi Ikeda; Tetsuya Kajimoto; Hirosato Kondo; Chi Huey Wong

doi:10.1016/S0960-894X(97)10022-1

Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

Tsuyoshi Ikeda, Tetsuya Kajimoto, Hirosato Kondo, Chi Huey Wong

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC₅₀ value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.

Original language	English
Pages (from-to)	2485-2490
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(97)10022-1
Publication status	Published - Oct 7 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)10022-1

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abstract = "In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.",

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AU - Kondo, Hirosato

AU - Wong, Chi Huey

PY - 1997/10/7

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AB - In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.

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IS - 19

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Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

Abstract

All Science Journal Classification (ASJC) codes

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