Design and semisynthesis of spermine-sensitive Ribonuclease S'

Itaru Hamachi, Yasuhiro Yamada, Ryoji Eboshi, Takashi Hiraoka, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Spermine-sensitive stabilization of semisynthetic Ribonuclease S' was successfully carried out by sequence specific incorporation of a poly-anion domain into α-helix region of S-peptide.

Original languageEnglish
Pages (from-to)1215-1218
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number9
Publication statusPublished - May 3 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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