Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis

Yuki Nakanishi; Wisaroot Sriitsaranusorn; Takaya Hattori; Kuang Chih Tso; Kenzo Shodo; Yasuo Terasawa; Yoshinori Sunaga; Hironari Takehara; Makito Haruta; Hiroyuki Tashiro; Kiyotaka Sasagawa; Jun Ohta

doi:10.35848/1347-4065/ad1fad

Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis

Yuki Nakanishi, Wisaroot Sriitsaranusorn, Takaya Hattori, Kuang Chih Tso, Kenzo Shodo, Yasuo Terasawa, Yoshinori Sunaga, Hironari Takehara, Makito Haruta, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta

Division of Medical Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The CMOS chip integrates current sources and electrode selection circuits. This integration enables stimulation current control from multiple electrodes with minimal wires. In this study, we constructed a validation system with 49 electrodes capable of visually observing stimulation current outputs. The validation results show that it is possible to configure stimulation conditions in approximately 9.3 μs per electrode, and we demonstrated the ability to complete one frame, including the stimulation time, within approximately 11 ms. We also demonstrated parallel current stimulation from multiple electrodes using an in vitro experiment.

Original language	English
Article number	03SP22
Journal	Japanese journal of applied physics
Volume	63
Issue number	3
DOIs	https://doi.org/10.35848/1347-4065/ad1fad
Publication status	Published - Mar 1 2024

All Science Journal Classification (ASJC) codes

General Engineering
General Physics and Astronomy

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title = "Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis",

abstract = "We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The CMOS chip integrates current sources and electrode selection circuits. This integration enables stimulation current control from multiple electrodes with minimal wires. In this study, we constructed a validation system with 49 electrodes capable of visually observing stimulation current outputs. The validation results show that it is possible to configure stimulation conditions in approximately 9.3 μs per electrode, and we demonstrated the ability to complete one frame, including the stimulation time, within approximately 11 ms. We also demonstrated parallel current stimulation from multiple electrodes using an in vitro experiment.",

author = "Yuki Nakanishi and Wisaroot Sriitsaranusorn and Takaya Hattori and Tso, {Kuang Chih} and Kenzo Shodo and Yasuo Terasawa and Yoshinori Sunaga and Hironari Takehara and Makito Haruta and Hiroyuki Tashiro and Kiyotaka Sasagawa and Jun Ohta",

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T1 - Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis

AU - Nakanishi, Yuki

AU - Sriitsaranusorn, Wisaroot

AU - Hattori, Takaya

AU - Tso, Kuang Chih

AU - Shodo, Kenzo

AU - Terasawa, Yasuo

AU - Sunaga, Yoshinori

AU - Takehara, Hironari

AU - Haruta, Makito

AU - Tashiro, Hiroyuki

AU - Sasagawa, Kiyotaka

AU - Ohta, Jun

PY - 2024/3/1

Y1 - 2024/3/1

N2 - We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The CMOS chip integrates current sources and electrode selection circuits. This integration enables stimulation current control from multiple electrodes with minimal wires. In this study, we constructed a validation system with 49 electrodes capable of visually observing stimulation current outputs. The validation results show that it is possible to configure stimulation conditions in approximately 9.3 μs per electrode, and we demonstrated the ability to complete one frame, including the stimulation time, within approximately 11 ms. We also demonstrated parallel current stimulation from multiple electrodes using an in vitro experiment.

AB - We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The CMOS chip integrates current sources and electrode selection circuits. This integration enables stimulation current control from multiple electrodes with minimal wires. In this study, we constructed a validation system with 49 electrodes capable of visually observing stimulation current outputs. The validation results show that it is possible to configure stimulation conditions in approximately 9.3 μs per electrode, and we demonstrated the ability to complete one frame, including the stimulation time, within approximately 11 ms. We also demonstrated parallel current stimulation from multiple electrodes using an in vitro experiment.

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Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis

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