Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress

Kazunori Sano; Emi Koushi; Keiichi Irie; Sei Higuchi; Ryota Tsuchihashi; Junei Kinjo; Nobuaki Egashira; Ryozo Oishi; Naoki Uchida; Hiroshi Nagai; Ryoji Nishimura; Hiroyuki Tanaka; Satoshi Morimoto; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara

doi:10.1248/bpb.32.2065

Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress

Kazunori Sano, Emi Koushi, Keiichi Irie, Sei Higuchi, Ryota Tsuchihashi, Junei Kinjo, Nobuaki Egashira, Ryozo Oishi, Naoki Uchida, Hiroshi Nagai, Ryoji Nishimura, Hiroyuki Tanaka, Satoshi Morimoto, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB1 receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB₁ receptor, thereby increasing the risk of depression.

Original language	English
Pages (from-to)	2065-2067
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	32
Issue number	12
DOIs	https://doi.org/10.1248/bpb.32.2065
Publication status	Published - Dec 2009

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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Sano, K., Koushi, E., Irie, K., Higuchi, S., Tsuchihashi, R., Kinjo, J., Egashira, N., Oishi, R., Uchida, N., Nagai, H., Nishimura, R., Tanaka, H., Morimoto, S., Mishima, K., Iwasaki, K., & Fujiwara, M. (2009). Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress. Biological and Pharmaceutical Bulletin, 32(12), 2065-2067. https://doi.org/10.1248/bpb.32.2065

Sano, K, Koushi, E, Irie, K, Higuchi, S, Tsuchihashi, R, Kinjo, J, Egashira, N, Oishi, R, Uchida, N, Nagai, H, Nishimura, R, Tanaka, H, Morimoto, S, Mishima, K, Iwasaki, K & Fujiwara, M 2009, 'Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress', Biological and Pharmaceutical Bulletin, vol. 32, no. 12, pp. 2065-2067. https://doi.org/10.1248/bpb.32.2065

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abstract = "The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB1 receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB1 receptor, thereby increasing the risk of depression.",

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AU - Tsuchihashi, Ryota

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AU - Uchida, Naoki

AU - Nagai, Hiroshi

AU - Nishimura, Ryoji

AU - Tanaka, Hiroyuki

AU - Morimoto, Satoshi

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Fujiwara, Michihiro

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Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress

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