Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress

Kazunori Sano, Emi Koushi, Keiichi Irie, Sei Higuchi, Ryota Tsuchihashi, Junei Kinjo, Nobuaki Egashira, Ryozo Oishi, Naoki Uchida, Hiroshi Nagai, Ryoji Nishimura, Hiroyuki Tanaka, Satoshi Morimoto, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB1 receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB1 receptor, thereby increasing the risk of depression.

Original languageEnglish
Pages (from-to)2065-2067
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number12
Publication statusPublished - Dec 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science


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