Dehydroepiandrosterone

Yukiko Ogino, Shinichi Miyagawa, Taisen Iguchi

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

DHEA and its sulfated form, DHEAS, are the most abundant endogenous steroids in human circulation, and are mainly produced in the adrenal cortex. The synthesis of DHEA is stimulated by ACTH secreted by the pituitary gland. DHEA is converted from pregnenolone by CYP17 (17α-hydroxylase, 17,20-lyase). DHEA can be converted to androstenedione by 3β-HSD, and subsequently to active androgens and estrogens. The decline of both circulating and brain DHEA with age is implicated in cardiovascular and neural diseases and an increased risk of carcinogenesis. High levels of DHEA and DHEAS induce precocious puberty in children.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
PublisherElsevier
Pages513-514
Number of pages2
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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