Dehydroepiandrosterone

Yukiko Ogino; Taisen Iguchi; Shinichi Miyagawa

doi:10.1016/B978-0-12-820649-2.00252-7

Dehydroepiandrosterone

Yukiko Ogino, Taisen Iguchi, Shinichi Miyagawa

Attached Promotive Center for International Education and Research of Agriculture

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

DHEA and its sulfated form, DHEAS, are the most abundant endogenous steroids in human circulation, and are mainly produced in the adrenal cortex. The synthesis of DHEA is stimulated by ACTH secreted by the pituitary gland. DHEA is converted from pregnenolone by CYP17 (17α-hydroxylase, 17, 20-lyase). DHEA can be converted to androstenedione by 3β-HSD, and subsequently to active androgens and estrogens. The decline of both circulating and brain DHEA with age is implicated in cardiovascular and neural diseases and an increased risk of carcinogenesis. High levels of DHEA and DHEAS induce precocious puberty in children.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	915-916
Number of pages	2
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00252-7
Publication status	Published - Jan 1 2021

All Science Journal Classification (ASJC) codes

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-820649-2.00252-7

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title = "Dehydroepiandrosterone",

abstract = "DHEA and its sulfated form, DHEAS, are the most abundant endogenous steroids in human circulation, and are mainly produced in the adrenal cortex. The synthesis of DHEA is stimulated by ACTH secreted by the pituitary gland. DHEA is converted from pregnenolone by CYP17 (17α-hydroxylase, 17, 20-lyase). DHEA can be converted to androstenedione by 3β-HSD, and subsequently to active androgens and estrogens. The decline of both circulating and brain DHEA with age is implicated in cardiovascular and neural diseases and an increased risk of carcinogenesis. High levels of DHEA and DHEAS induce precocious puberty in children.",

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T1 - Dehydroepiandrosterone

AU - Ogino, Yukiko

AU - Iguchi, Taisen

AU - Miyagawa, Shinichi

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N2 - DHEA and its sulfated form, DHEAS, are the most abundant endogenous steroids in human circulation, and are mainly produced in the adrenal cortex. The synthesis of DHEA is stimulated by ACTH secreted by the pituitary gland. DHEA is converted from pregnenolone by CYP17 (17α-hydroxylase, 17, 20-lyase). DHEA can be converted to androstenedione by 3β-HSD, and subsequently to active androgens and estrogens. The decline of both circulating and brain DHEA with age is implicated in cardiovascular and neural diseases and an increased risk of carcinogenesis. High levels of DHEA and DHEAS induce precocious puberty in children.

AB - DHEA and its sulfated form, DHEAS, are the most abundant endogenous steroids in human circulation, and are mainly produced in the adrenal cortex. The synthesis of DHEA is stimulated by ACTH secreted by the pituitary gland. DHEA is converted from pregnenolone by CYP17 (17α-hydroxylase, 17, 20-lyase). DHEA can be converted to androstenedione by 3β-HSD, and subsequently to active androgens and estrogens. The decline of both circulating and brain DHEA with age is implicated in cardiovascular and neural diseases and an increased risk of carcinogenesis. High levels of DHEA and DHEAS induce precocious puberty in children.

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M3 - Chapter

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BT - Handbook of Hormones

PB - Elsevier

ER -

Dehydroepiandrosterone

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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