DHEA and its sulfated form, DHEAS, are the most abundant endogenous steroids in human circulation, and are mainly produced in the adrenal cortex. The synthesis of DHEA is stimulated by ACTH secreted by the pituitary gland. DHEA is converted from pregnenolone by CYP17 (17α-hydroxylase, 17, 20-lyase). DHEA can be converted to androstenedione by 3β-HSD, and subsequently to active androgens and estrogens. The decline of both circulating and brain DHEA with age is implicated in cardiovascular and neural diseases and an increased risk of carcinogenesis. High levels of DHEA and DHEAS induce precocious puberty in children.
|Title of host publication||Handbook of Hormones|
|Subtitle of host publication||Comparative Endocrinology for Basic and Clinical Research|
|Number of pages||2|
|Publication status||Published - Jan 1 2021|
All Science Journal Classification (ASJC) codes