Deep and future insights into neuromodulation therapies for heart failure

Takuya Kishi

    Research output: Contribution to journalReview articlepeer-review

    11 Citations (Scopus)


    Major pathophysiology of heart failure is an autonomic nervous system dysfunction as a result of excess sympathoexcitation and/or withdrawal of vagal nerve activity. Although we already have various pharmacological and non-pharmacological therapies for heart failure, survival of heart failure patients remains around 50%. To achieve further reductions in morbidity and mortality of heart failure, neuromodulations with devices, such as baroreflex activating therapy, vagal nerve stimulation, renal sympathetic denervation, spinal cord stimulation, and left cardiac sympathetic denervation, have been expected. Although all of these neuromodulations have benefits on heart failure, efficacy, and safety in preclinical and small-sized clinical studies, the benefits on heart failure have been insufficient and controversial compared to our expectations in large-sized randomized trials. However, we should develop and apply these novel therapies for the patients with heart failure in the near future.

    Original languageEnglish
    Pages (from-to)368-372
    Number of pages5
    JournalJournal of Cardiology
    Issue number5
    Publication statusPublished - Nov 1 2016

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine


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