TY - JOUR
T1 - Dedifferentiated chondrosarcoma of the cervical spine
T2 - A case report
AU - Matsumoto, Yoshihiro
AU - Takahashi, Yusuke
AU - Harimaya, Katsumi
AU - Nakagawa, Takeshi
AU - Kawaguchi, Kenichi
AU - Okada, Seiji
AU - Hayashida, Mitsumasa
AU - Doi, Toshio
AU - Sakamoto, Akio
AU - Matsunobu, Tomoya
AU - Oda, Yoshinao
AU - Iwamoto, Yukihide
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (#23592192).
PY - 2013/2/2
Y1 - 2013/2/2
N2 - Dedifferentiated chondrosarcoma (DDCS) is a rare and aggressive bone tumor with poor prognosis. Primary DDCS of the mobile spine is extremely rare, particularly in the cervical spine. We herein describe a first case of cervical DDCS in an 81-year-old male presenting with a slowly growing mass. Radiographs showed an expansion of the cortical contour of the C2 lamina and a soft tissue mass with punctate calcification. Magnetic resonance imaging demonstrated a lobulated lesion expanding over the entire lamina and pedicles of C2 with the tumor protuberant to the adjacent soft tissue. A complete tumor resection was performed. Histologically, the majority of the tumor was a low-grade chondrosarcoma component. However, atypical spindle cells that had proliferated in a fascicular pattern with a collagenous stroma, mimicking fibrosarcoma, were focally observed without a transitional zone, and these features confirmed that the tumor was DDCS.
AB - Dedifferentiated chondrosarcoma (DDCS) is a rare and aggressive bone tumor with poor prognosis. Primary DDCS of the mobile spine is extremely rare, particularly in the cervical spine. We herein describe a first case of cervical DDCS in an 81-year-old male presenting with a slowly growing mass. Radiographs showed an expansion of the cortical contour of the C2 lamina and a soft tissue mass with punctate calcification. Magnetic resonance imaging demonstrated a lobulated lesion expanding over the entire lamina and pedicles of C2 with the tumor protuberant to the adjacent soft tissue. A complete tumor resection was performed. Histologically, the majority of the tumor was a low-grade chondrosarcoma component. However, atypical spindle cells that had proliferated in a fascicular pattern with a collagenous stroma, mimicking fibrosarcoma, were focally observed without a transitional zone, and these features confirmed that the tumor was DDCS.
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U2 - 10.1186/1477-7819-11-32
DO - 10.1186/1477-7819-11-32
M3 - Article
C2 - 23375124
AN - SCOPUS:84873040042
SN - 1477-7819
VL - 11
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
M1 - 32
ER -