Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin

Naoki Matsuoka, Yoshihiro Ogawa, Hiroaki Masuzaki, Ken Ebihara, Megumi Aizawa-Abe, Noriko Satoh, Eiichiro Ishikawa, Yukio Fujisawa, Atsushi Kosaki, Kazunori Yamada, Hideshi Kuzuya, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Leptin is an adipocyte-derived circulating satiety factor with a variety of biological effects. Evidence has accumulated suggesting that leptin may modulate glucose and lipid metabolism. In the present study, we examined lipid metabolism in transgenic skinny mice with elevated plasma leptin concentrations. The plasma concentrations of triglycerides and free fatty acids in transgenic skinny mice were 71.5 (P < 0.01) and 89.1% (P < 0.05) of those in their nontransgenic littermates, respectively. Separation of plasma into lipoprotein classes by ultracentrifugation revealed that very low density lipoprotein-triglyceride concentrations were markedly reduced in transgenic skinny mice relative to the controls. The clearance of triglycerides estimated by a fat-loading test was enhanced in transgenic skinny mice; the triglyceride concentration in transgenic skinny mice 3 h after fat loading was 39.7% (P < 0.05) of that of their nontransgenic littermates. Postheparin plasma lipoprotein lipase activity increased 1.4-fold (P < 0.05) in transgenic skinny mice. Our data demonstrated a significant reduction in plasma triglyceride concentrations, accompanied by increased lipoprotein lipase activity in transgenic skinny mice overexpressing leptin, suggesting that leptin plays a role in long-term triglyceride metabolism.

Original languageEnglish
Pages (from-to)E334-E339
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number2 43-2
Publication statusPublished - Feb 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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