Cytotoxin-converting phages, φCTX and PS21, are R pyocin-related phages

Tetsuya Hayashi, Hideki Matsumoto, Makoto Ohnishi, Shin ichi Yokota, Tomoyuki Shinomiya, Makoto Kageyama, Yoshiro Terawaki

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


φCTX is a temperate phage of Pseudomonas aeruginosa harbouring the ctx gene that encodes cytotoxin (CTX). We identified φCTX as an R pyocin-related phage, by serological and molecular analysis, based on the findings that the infectivity of the phage was inhibited with the antisera directed R pyocins and R pyocin-related phages and that the φCTX genome showed DNA homology to the genome of PS17 (a representative of the R pyocin-related phages) as well as to the pyocin R2 genes. Another new CTX-converting, R pyocin-related phage named PS21 was isolated from a CTX-producing strain of P. aeruginosa, suggesting the distribution of the ctx gene by certain members of R pyocin-related phage family.

Original languageEnglish
Pages (from-to)239-344
Number of pages106
JournalFEMS microbiology letters
Issue number3
Publication statusPublished - Oct 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics


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