Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

Debabrata Acharya; Anne Claire Mitaine-Offer; Nutan Kaushik; Tomofumi Miyamoto; Thomas Paululat; Jean François Mirjolet; Olivier Duchamp; Marie Aleth Lacaille-Dubois

doi:10.1021/np800559z

Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

Debabrata Acharya, Anne Claire Mitaine-Offer, Nutan Kaushik, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	1
DOIs	https://doi.org/10.1021/np800559z
Publication status	Published - Jan 2009

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np800559z

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abstract = "Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).",

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AU - Acharya, Debabrata

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AU - Miyamoto, Tomofumi

AU - Paululat, Thomas

AU - Mirjolet, Jean François

AU - Duchamp, Olivier

AU - Lacaille-Dubois, Marie Aleth

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Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

Abstract

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