Cytotoxic lavandulyl flavanones from Sophora flavescens

Tai Hyun Kang; Sei Joon Jeong; Won Gil Ko; Na Young Kim; Byung Hoon Lee; Masanori Inagaki; Tomofumi Miyamoto; Ryuichi Higuchi; Youn Chul Kim

doi:10.1021/np990567x

Cytotoxic lavandulyl flavanones from Sophora flavescens

Tai Hyun Kang, Sei Joon Jeong, Won Gil Ko, Na Young Kim, Byung Hoon Lee, Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Higuchi, Youn Chul Kim

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (- )-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

Original language	English
Pages (from-to)	680-681
Number of pages	2
Journal	Journal of Natural Products
Volume	63
Issue number	5
DOIs	https://doi.org/10.1021/np990567x
Publication status	Published - May 2000

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np990567x

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title = "Cytotoxic lavandulyl flavanones from Sophora flavescens",

abstract = "Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (- )-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.",

author = "Kang, {Tai Hyun} and Jeong, {Sei Joon} and Ko, {Won Gil} and Kim, {Na Young} and Lee, {Byung Hoon} and Masanori Inagaki and Tomofumi Miyamoto and Ryuichi Higuchi and Kim, {Youn Chul}",

year = "2000",

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doi = "10.1021/np990567x",

language = "English",

volume = "63",

pages = "680--681",

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T1 - Cytotoxic lavandulyl flavanones from Sophora flavescens

AU - Kang, Tai Hyun

AU - Jeong, Sei Joon

AU - Ko, Won Gil

AU - Kim, Na Young

AU - Lee, Byung Hoon

AU - Inagaki, Masanori

AU - Miyamoto, Tomofumi

AU - Higuchi, Ryuichi

AU - Kim, Youn Chul

PY - 2000/5

Y1 - 2000/5

N2 - Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (- )-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

AB - Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (- )-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

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Cytotoxic lavandulyl flavanones from Sophora flavescens

Abstract

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