Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Rosalind Pei Theng Kim; Vicky Bihud; Khalit Bin Mohamad; Kok Hoong Leong; Jamaludin Bin Mohamad; Fasihuddin Bin Ahmad; Hazrina Hazni; Noraini Kasim; Siti Nadiah Abdul Halim; Khalijah Awang

doi:10.3390/molecules18010128

Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Rosalind Pei Theng Kim, Vicky Bihud, Khalit Bin Mohamad, Kok Hoong Leong, Jamaludin Bin Mohamad, Fasihuddin Bin Ahmad, Hazrina Hazni, Noraini Kasim, Siti Nadiah Abdul Halim, Khalijah Awang

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

Original language	English
Pages (from-to)	128-139
Number of pages	12
Journal	Molecules
Volume	18
Issue number	1
DOIs	https://doi.org/10.3390/molecules18010128
Publication status	Published - Jan 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules18010128

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title = "Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh",

abstract = "Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.",

author = "Kim, {Rosalind Pei Theng} and Vicky Bihud and {Bin Mohamad}, Khalit and Leong, {Kok Hoong} and {Bin Mohamad}, Jamaludin and {Bin Ahmad}, Fasihuddin and Hazrina Hazni and Noraini Kasim and Halim, {Siti Nadiah Abdul} and Khalijah Awang",

year = "2013",

month = jan,

doi = "10.3390/molecules18010128",

language = "English",

volume = "18",

pages = "128--139",

journal = "Molecules",

issn = "1420-3049",

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T1 - Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

AU - Kim, Rosalind Pei Theng

AU - Bihud, Vicky

AU - Bin Mohamad, Khalit

AU - Leong, Kok Hoong

AU - Bin Mohamad, Jamaludin

AU - Bin Ahmad, Fasihuddin

AU - Hazni, Hazrina

AU - Kasim, Noraini

AU - Halim, Siti Nadiah Abdul

AU - Awang, Khalijah

PY - 2013/1

Y1 - 2013/1

N2 - Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

AB - Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

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DO - 10.3390/molecules18010128

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SN - 1420-3049

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EP - 139

JO - Molecules

JF - Molecules

IS - 1

ER -

Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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