Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Olivier Placide Noté; Anne Claire Mitaine-Offer; Tomofumi Miyamoto; Thomas Paululat; Jean François Mirjolet; Olivier Duchamp; Dieudonné Emmanuel Pegnyemb; Marie Aleth Lacaille-Dubois

doi:10.1021/np900126r

Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Olivier Placide Noté, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Dieudonné Emmanuel Pegnyemb, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC₅₀ 4.2 μM for 1 and 2.7 μM for 3) and HT-29 (IC₅₀ 6.7 μM for 1 and 7.9 μM for 3) cell lines.

Original language	English
Pages (from-to)	1725-1730
Number of pages	6
Journal	Journal of Natural Products
Volume	72
Issue number	10
DOIs	https://doi.org/10.1021/np900126r
Publication status	Published - Oct 23 2009

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np900126r

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abstract = "Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 μM for 1 and 2.7 μM for 3) and HT-29 (IC50 6.7 μM for 1 and 7.9 μM for 3) cell lines.",

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AU - Noté, Olivier Placide

AU - Mitaine-Offer, Anne Claire

AU - Miyamoto, Tomofumi

AU - Paululat, Thomas

AU - Mirjolet, Jean François

AU - Duchamp, Olivier

AU - Pegnyemb, Dieudonné Emmanuel

AU - Lacaille-Dubois, Marie Aleth

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Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Abstract

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