Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma (HCC)

Hiroaki Wakiyama; Takaaki Masuda; Yushi Motomura; H. U. Qingjiang; Taro Tobo; Hidetoshi Eguchi; Katsumi Sakamoto; Masakazu Hirakawa; Hiroshi Honda; Koshi Mimori

doi:10.21873/anticanres.13030

Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma (HCC)

Hiroaki Wakiyama, Takaaki Masuda, Yushi Motomura, H. U. Qingjiang, Taro Tobo, Hidetoshi Eguchi, Katsumi Sakamoto, Masakazu Hirakawa, Hiroshi Honda, Koshi Mimori

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Background/Aim: The cytolytic activity (CYT) score is a new index of cancer immunity calculated from the mRNA expression levels of GZMA and PRF1. We assessed the clinical significance of the CYT score in HCC. Materials and Methods: The calculated CYT scores of peripheral blood cells (GSE24759), cell lines (CCLE) and HCC tissues (TCGA, GSE14520 and Kyushu cohorts) were assessed. Then, immunohistochemical analysis (IHC) of GZMA and PRF1 was performed. Results: The CYT scores of HCC tissues were lower than those of non-cancerous tissues. The 5-year recurrence-free survival of patients with low CYT scores was significantly shorter than that of patients with high CYT scores. Multivariate analysis indicated that the CYT score was an independent prognostic factor for RFS in TCGA and GSE14520 cohorts. Conclusion: CYT score could be a useful prognostic biomarker in HCC, possibly through reflecting the host immune status.

Original language	English
Pages (from-to)	6631-6638
Number of pages	8
Journal	Anticancer research
Volume	38
Issue number	12
DOIs	https://doi.org/10.21873/anticanres.13030
Publication status	Published - Dec 2018

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.13030

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title = "Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma (HCC)",

abstract = "Background/Aim: The cytolytic activity (CYT) score is a new index of cancer immunity calculated from the mRNA expression levels of GZMA and PRF1. We assessed the clinical significance of the CYT score in HCC. Materials and Methods: The calculated CYT scores of peripheral blood cells (GSE24759), cell lines (CCLE) and HCC tissues (TCGA, GSE14520 and Kyushu cohorts) were assessed. Then, immunohistochemical analysis (IHC) of GZMA and PRF1 was performed. Results: The CYT scores of HCC tissues were lower than those of non-cancerous tissues. The 5-year recurrence-free survival of patients with low CYT scores was significantly shorter than that of patients with high CYT scores. Multivariate analysis indicated that the CYT score was an independent prognostic factor for RFS in TCGA and GSE14520 cohorts. Conclusion: CYT score could be a useful prognostic biomarker in HCC, possibly through reflecting the host immune status.",

author = "Hiroaki Wakiyama and Takaaki Masuda and Yushi Motomura and Qingjiang, {H. U.} and Taro Tobo and Hidetoshi Eguchi and Katsumi Sakamoto and Masakazu Hirakawa and Hiroshi Honda and Koshi Mimori",

year = "2018",

month = dec,

doi = "10.21873/anticanres.13030",

language = "English",

volume = "38",

pages = "6631--6638",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "12",

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TY - JOUR

T1 - Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma (HCC)

AU - Wakiyama, Hiroaki

AU - Masuda, Takaaki

AU - Motomura, Yushi

AU - Qingjiang, H. U.

AU - Tobo, Taro

AU - Eguchi, Hidetoshi

AU - Sakamoto, Katsumi

AU - Hirakawa, Masakazu

AU - Honda, Hiroshi

AU - Mimori, Koshi

PY - 2018/12

Y1 - 2018/12

N2 - Background/Aim: The cytolytic activity (CYT) score is a new index of cancer immunity calculated from the mRNA expression levels of GZMA and PRF1. We assessed the clinical significance of the CYT score in HCC. Materials and Methods: The calculated CYT scores of peripheral blood cells (GSE24759), cell lines (CCLE) and HCC tissues (TCGA, GSE14520 and Kyushu cohorts) were assessed. Then, immunohistochemical analysis (IHC) of GZMA and PRF1 was performed. Results: The CYT scores of HCC tissues were lower than those of non-cancerous tissues. The 5-year recurrence-free survival of patients with low CYT scores was significantly shorter than that of patients with high CYT scores. Multivariate analysis indicated that the CYT score was an independent prognostic factor for RFS in TCGA and GSE14520 cohorts. Conclusion: CYT score could be a useful prognostic biomarker in HCC, possibly through reflecting the host immune status.

AB - Background/Aim: The cytolytic activity (CYT) score is a new index of cancer immunity calculated from the mRNA expression levels of GZMA and PRF1. We assessed the clinical significance of the CYT score in HCC. Materials and Methods: The calculated CYT scores of peripheral blood cells (GSE24759), cell lines (CCLE) and HCC tissues (TCGA, GSE14520 and Kyushu cohorts) were assessed. Then, immunohistochemical analysis (IHC) of GZMA and PRF1 was performed. Results: The CYT scores of HCC tissues were lower than those of non-cancerous tissues. The 5-year recurrence-free survival of patients with low CYT scores was significantly shorter than that of patients with high CYT scores. Multivariate analysis indicated that the CYT score was an independent prognostic factor for RFS in TCGA and GSE14520 cohorts. Conclusion: CYT score could be a useful prognostic biomarker in HCC, possibly through reflecting the host immune status.

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DO - 10.21873/anticanres.13030

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SN - 0250-7005

VL - 38

SP - 6631

EP - 6638

JO - Anticancer research

JF - Anticancer research

IS - 12

ER -

Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma (HCC)

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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