@article{3f3934609f6a48f49cbd247df8d82216,
title = "Cytolytic activity (CYT) score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma (HCC)",
abstract = "Background/Aim: The cytolytic activity (CYT) score is a new index of cancer immunity calculated from the mRNA expression levels of GZMA and PRF1. We assessed the clinical significance of the CYT score in HCC. Materials and Methods: The calculated CYT scores of peripheral blood cells (GSE24759), cell lines (CCLE) and HCC tissues (TCGA, GSE14520 and Kyushu cohorts) were assessed. Then, immunohistochemical analysis (IHC) of GZMA and PRF1 was performed. Results: The CYT scores of HCC tissues were lower than those of non-cancerous tissues. The 5-year recurrence-free survival of patients with low CYT scores was significantly shorter than that of patients with high CYT scores. Multivariate analysis indicated that the CYT score was an independent prognostic factor for RFS in TCGA and GSE14520 cohorts. Conclusion: CYT score could be a useful prognostic biomarker in HCC, possibly through reflecting the host immune status.",
author = "Hiroaki Wakiyama and Takaaki Masuda and Yushi Motomura and Qingjiang, {H. U.} and Taro Tobo and Hidetoshi Eguchi and Katsumi Sakamoto and Masakazu Hirakawa and Hiroshi Honda and Koshi Mimori",
note = "Funding Information: The Authors thank K. Oda, M. Kasagi, M. Sakuma, N. Mishima, T. Kawano and J. Takano for their technical assistance. This work was supported in part by the following grants and foundations: Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Science Research (Grant Numbers JP16K07177, JP16K10543, JP16K19197, JP16K19832, JP17K16454, JP17K16521, JP17K10593, JP17K19608 and JP18K07755); OITA Cancer Research Foundation; Daiwa Securities Health Foundation; Grant-in-Aid for Scientific Research on Innovative Areas (15H0912); Priority Issue on Post-K computer (hp170227) (hp170227, hp160219); JSPS KAKENHI (15H05707); Eli Lilly Japan K.K. Grant; Japanese Foundation for Multidisciplinary Treatment of Cancer. Publisher Copyright: {\textcopyright} 2018 International Institute of Anticancer Research. All rights reserved.",
year = "2018",
month = dec,
doi = "10.21873/anticanres.13030",
language = "English",
volume = "38",
pages = "6631--6638",
journal = "Anticancer research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "12",
}
