TY - JOUR
T1 - Cytokines and chemokines in the epidermis
AU - Uchi, Hiroshi
AU - Terao, Hiroshi
AU - Koga, Tetsuya
AU - Furue, Masutaka
N1 - Funding Information:
This work was supported by grants from the Ministry of Education, Science, Sports and Culture of Japan, and also from the Ministry of Health and Welfare of Japan.
PY - 2000
Y1 - 2000
N2 - Keratinocytes (KC) produce a vast repertoire of cytokines, including interleukins, growth factors, colony stimulating factors, and chemokines. Under normal conditions, most of them are not synthesized or remain in the cytoplasm, but external stimuli, such as trauma, bacterial infections, chemical substances, or ultraviolet irradiation induce the production and release of these cytokines from KC. KC-derived cytokines regulate the immune and inflammatory responses through their receptors on KC, Langerhans cells, dermal fibroblasts and endothelial cells, and infiltrating T-cells.
AB - Keratinocytes (KC) produce a vast repertoire of cytokines, including interleukins, growth factors, colony stimulating factors, and chemokines. Under normal conditions, most of them are not synthesized or remain in the cytoplasm, but external stimuli, such as trauma, bacterial infections, chemical substances, or ultraviolet irradiation induce the production and release of these cytokines from KC. KC-derived cytokines regulate the immune and inflammatory responses through their receptors on KC, Langerhans cells, dermal fibroblasts and endothelial cells, and infiltrating T-cells.
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U2 - 10.1016/S0923-1811(00)00138-9
DO - 10.1016/S0923-1811(00)00138-9
M3 - Article
C2 - 11137393
AN - SCOPUS:0034541433
SN - 0923-1811
VL - 24
SP - S29-S38
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
IS - SUPPL. 1
ER -