Cytokines and chemokines in the epidermis

Hiroshi Uchi, Hiroshi Terao, Tetsuya Koga, Masutaka Furue

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)


Keratinocytes (KC) produce a vast repertoire of cytokines, including interleukins, growth factors, colony stimulating factors, and chemokines. Under normal conditions, most of them are not synthesized or remain in the cytoplasm, but external stimuli, such as trauma, bacterial infections, chemical substances, or ultraviolet irradiation induce the production and release of these cytokines from KC. KC-derived cytokines regulate the immune and inflammatory responses through their receptors on KC, Langerhans cells, dermal fibroblasts and endothelial cells, and infiltrating T-cells.

Original languageEnglish
Pages (from-to)S29-S38
JournalJournal of Dermatological Science
Issue numberSUPPL. 1
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology


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