Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

Peng Chen; Maki Ashida; Hisashi Doi; Yusuke Tsutsumi; Zenji Horita; Takao Hanawa

doi:10.2320/matertrans.MI201515

Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

Peng Chen, Maki Ashida, Hisashi Doi, Yusuke Tsutsumi, Zenji Horita, Takao Hanawa

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.

Original language	English
Pages (from-to)	2020-2025
Number of pages	6
Journal	Materials Transactions
Volume	57
Issue number	12
DOIs	https://doi.org/10.2320/matertrans.MI201515
Publication status	Published - 2016

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing",

abstract = "In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.",

author = "Peng Chen and Maki Ashida and Hisashi Doi and Yusuke Tsutsumi and Zenji Horita and Takao Hanawa",

note = "Publisher Copyright: {\textcopyright} 2016 The Japan Institute of Metals and Materials.",

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doi = "10.2320/matertrans.MI201515",

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T1 - Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

AU - Chen, Peng

AU - Ashida, Maki

AU - Doi, Hisashi

AU - Tsutsumi, Yusuke

AU - Horita, Zenji

AU - Hanawa, Takao

PY - 2016

Y1 - 2016

N2 - In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.

AB - In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.

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EP - 2025

JO - Materials Transactions

JF - Materials Transactions

IS - 12

ER -

Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

Abstract

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