CYLD in Ubiquitin Signaling and Tumor Pathogenesis

Fumiyo Ikeda, Ivan Dikic

Research output: Contribution to journalShort surveypeer-review

26 Citations (Scopus)


Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors. In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-κB and activates transcription of proliferation genes in response to growth signals.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
Issue number4
Publication statusPublished - May 19 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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