Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation

Kenjirou Kamezaki; Takahiro Fukuda; Shigeyoshi Makino; Mine Harada

doi:10.2169/internalmedicine.44.120

Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation

Kenjirou Kamezaki, Takahiro Fukuda, Shigeyoshi Makino, Mine Harada

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing cyclophosphamide (CY) followed by autologous peripheral blood stem cell transplantation. He suffered from CY-induced cardiomyopathy beginning six days after the administration of high-dose CY. The predictable factors associated with the onset of CY-induced cardiomyopathy are not precisely known. It is suggested that the history of mediastinal irradiation was responsible for the onset of cardiomyopathy.

Original language	English
Pages (from-to)	120-123
Number of pages	4
Journal	Internal Medicine
Volume	44
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.44.120
Publication status	Published - Feb 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.44.120

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abstract = "A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing cyclophosphamide (CY) followed by autologous peripheral blood stem cell transplantation. He suffered from CY-induced cardiomyopathy beginning six days after the administration of high-dose CY. The predictable factors associated with the onset of CY-induced cardiomyopathy are not precisely known. It is suggested that the history of mediastinal irradiation was responsible for the onset of cardiomyopathy.",

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AU - Makino, Shigeyoshi

AU - Harada, Mine

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AB - A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing cyclophosphamide (CY) followed by autologous peripheral blood stem cell transplantation. He suffered from CY-induced cardiomyopathy beginning six days after the administration of high-dose CY. The predictable factors associated with the onset of CY-induced cardiomyopathy are not precisely known. It is suggested that the history of mediastinal irradiation was responsible for the onset of cardiomyopathy.

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Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation

Abstract

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