Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation

Kazuya Shimoda; Kenjirou Kamesaki; Akihiko Numata; Kenichi Aoki; Tadashi Matsuda; Kenji Oritani; Sadafumi Tamiya; Kouji Kato; Ken Takase; Rie Imamura; Tetsuya Yamamoto; Toshihiro Miyamoto; Koji Nagafuji; Hisashi Gondo; Seiho Nagafuchi; Kei Ichi Nakayama; Mine Harada

doi:10.4049/jimmunol.169.9.4707

Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation

Kazuya Shimoda, Kenjirou Kamesaki, Akihiko Numata, Kenichi Aoki, Tadashi Matsuda, Kenji Oritani, Sadafumi Tamiya, Kouji Kato, Ken Takase, Rie Imamura, Tetsuya Yamamoto, Toshihiro Miyamoto, Koji Nagafuji, Hisashi Gondo, Seiho Nagafuchi, Kei Ichi Nakayama, Mine Harada

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52 Citations (Scopus)

Abstract

IFN-α inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-α inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-α-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-α signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis.

Original language	English
Pages (from-to)	4707-4711
Number of pages	5
Journal	Journal of Immunology
Volume	169
Issue number	9
DOIs	https://doi.org/10.4049/jimmunol.169.9.4707
Publication status	Published - Nov 1 2002

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.4049/jimmunol.169.9.4707

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Shimoda, K., Kamesaki, K., Numata, A., Aoki, K., Matsuda, T., Oritani, K., Tamiya, S., Kato, K., Takase, K., Imamura, R., Yamamoto, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K. I., & Harada, M. (2002). Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation. Journal of Immunology, 169(9), 4707-4711. https://doi.org/10.4049/jimmunol.169.9.4707

Shimoda, K, Kamesaki, K, Numata, A, Aoki, K, Matsuda, T, Oritani, K, Tamiya, S, Kato, K, Takase, K, Imamura, R, Yamamoto, T, Miyamoto, T, Nagafuji, K, Gondo, H, Nagafuchi, S, Nakayama, KI & Harada, M 2002, 'Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation', Journal of Immunology, vol. 169, no. 9, pp. 4707-4711. https://doi.org/10.4049/jimmunol.169.9.4707

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title = "Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation",

abstract = "IFN-α inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-α inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-α-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-α signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis.",

author = "Kazuya Shimoda and Kenjirou Kamesaki and Akihiko Numata and Kenichi Aoki and Tadashi Matsuda and Kenji Oritani and Sadafumi Tamiya and Kouji Kato and Ken Takase and Rie Imamura and Tetsuya Yamamoto and Toshihiro Miyamoto and Koji Nagafuji and Hisashi Gondo and Seiho Nagafuchi and Nakayama, {Kei Ichi} and Mine Harada",

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AU - Shimoda, Kazuya

AU - Kamesaki, Kenjirou

AU - Numata, Akihiko

AU - Aoki, Kenichi

AU - Matsuda, Tadashi

AU - Oritani, Kenji

AU - Tamiya, Sadafumi

AU - Kato, Kouji

AU - Takase, Ken

AU - Imamura, Rie

AU - Yamamoto, Tetsuya

AU - Miyamoto, Toshihiro

AU - Nagafuji, Koji

AU - Gondo, Hisashi

AU - Nagafuchi, Seiho

AU - Nakayama, Kei Ichi

AU - Harada, Mine

PY - 2002/11/1

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AB - IFN-α inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-α inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-α-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-α signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis.

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Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation

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