Cushing's Disease Preceding Sarcoidosis

Katsuto Takenaka, Toshihiko Yanase, Ryoichi Takayanagi, Masahumi Haji, Shoichiro Ikuyama, Hajime Nawata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We present a 32-year-old-woman with Cushing's disease and sarcoidosis. She had been diagnosed as having Cushing's disease in 1985. She had transsphenoidal surgery followed by pituitary radiation. Subsequently her plasma cortisol level gradually decreased to normal range. In 1991, she manifested bilateral hilar lymphadenopathy on chest X-ray, erythema nodosum, subcutaneous nodules and granulomatous uveitis. From the histological findings of the skin lesions, the patient was diagnosed as having sarcoidosis. Interestingly, an inverse relationship between the disease activity of sarcoidosis and the level of serum cortisol in Cushing's disease was observed in the clinical course of this patient. Co-existence of Cushing's disease and sarcoidosis is very rare. Since the therapeutic significance of steroids in sarcoidosis has been well established, this case provides insight to the relationship between sarcoidosis and steroids.

Original languageEnglish
Pages (from-to)580-583
Number of pages4
JournalInternal Medicine
Issue number6
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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