Current status of pediatric deceased donor liver transplantation: Lessons learned from a high-volume center in Japan where living donation remains predominant

Seisuke Sakamoto, Hajime Uchida, Seiichi Shimizu, Yusuke Yanagi, Masahiro Takeda, Tomomi Kubota, Yayoi Nakazato, Akinari Fukuda, Mureo Kasahara

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: In Japan, a recent gradual increase in deceased donor donation has expanded opportunities for pediatric patients to obtain deceased grafts. Methods: Forty-three children underwent deceased donor liver transplantation (DDLT) at our institute before February 2020. Twenty-five patients received a split or reduced graft and 18 patients received a whole graft. The clinical outcomes of DDLT were retrospectively analyzed. Results: The main organ resource was split/reduced grafts retrieved from adult donors; however, the number of whole grafts retrieved from pediatric donors has increased. The rates of major complications were similar in the two groups. The 5-year graft survival rate of patients who received a split/reduced graft (78.0%) was lower than that of patients who received a whole graft (88.9%; P =.40). The 3-year graft survival rates of patients who recently received a split/reduced graft and a whole graft improved to 92.3% and 91.7%, respectively. Conclusions: The recent amendment of the organ allocation system, especially the introduction of pediatric prioritization, can effectively increase the chance to obtain deceased donor grafts for pediatric DDLT in Japan. The recent refinements in donor and recipient selection and in the surgical technique of split DDLT can improve the outcomes of pediatric DDLT in Japan.

Original languageEnglish
Pages (from-to)1014-1022
Number of pages9
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume28
Issue number11
DOIs
Publication statusPublished - Nov 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

Fingerprint

Dive into the research topics of 'Current status of pediatric deceased donor liver transplantation: Lessons learned from a high-volume center in Japan where living donation remains predominant'. Together they form a unique fingerprint.

Cite this