C1-symmetric Rh/Phebox-catalyzed asymmetric alkynylation of α-ketoesters

Takashi Ohshima, Takahito Kawabata, Yosuke Takeuchi, Takahiro Kakinuma, Takanori Iwasaki, Takayuki Yonezawa, Hajime Murakami, Hisao Nishiyama, Kazushi Mashima

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


Thinking outside the box: A newly developed C1-symmetric Rh/Phebox complex efficiently catalyzed the asymmetric alkynylation of α-ketoester 1 with various aryl and alkyl substituted terminal alkynes to provide the corresponding chiral tertiary propargylic alcohols with up to 99 % ee (see scheme; TMS=trimethylsilyl).

Original languageEnglish
Pages (from-to)6296-6300
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number28
Publication statusPublished - Jul 4 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


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