CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

Takahisa Tateishi; Ryo Yamasaki; Masahito Tanaka; Takuya Matsushita; Hitoshi Kikuchi; Noriko Isobe; Yasumasa Ohyagi; Jun ichi Kira

doi:10.1016/j.jneuroim.2010.03.004

CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

Takahisa Tateishi, Ryo Yamasaki, Masahito Tanaka, Takuya Matsushita, Hitoshi Kikuchi, Noriko Isobe, Yasumasa Ohyagi, Jun ichi Kira

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

Original language	English
Pages (from-to)	76-81
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	222
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.03.004
Publication status	Published - May 2010

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2010.03.004

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title = "CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis",

abstract = "We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.",

author = "Takahisa Tateishi and Ryo Yamasaki and Masahito Tanaka and Takuya Matsushita and Hitoshi Kikuchi and Noriko Isobe and Yasumasa Ohyagi and Kira, {Jun ichi}",

note = "Funding Information: This work was supported by a grant-in-aid for young scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology, Japan .",

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T1 - CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

AU - Tateishi, Takahisa

AU - Yamasaki, Ryo

AU - Tanaka, Masahito

AU - Matsushita, Takuya

AU - Kikuchi, Hitoshi

AU - Isobe, Noriko

AU - Ohyagi, Yasumasa

AU - Kira, Jun ichi

N1 - Funding Information: This work was supported by a grant-in-aid for young scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology, Japan .

PY - 2010/5

Y1 - 2010/5

N2 - We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

AB - We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

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JO - Journal of Neuroimmunology

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CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

Abstract

All Science Journal Classification (ASJC) codes

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