Cronkhite-Canada syndrome associated with schizophrenia

Masaharu Nakayama, Hiromi Muta, Shinichi Somada, Toyoki Maeda, Toshitaka Mutoh, Kanako Shimizu, Yoko Suehiro, Terumasa Hisano, Ryo Kurita, Takeshi Shiraishi, Masaki Mori, Yasuji Yoshikawa, Nobuto Tsunetomi, Akihiro Uchida, Kenzaburo Tani

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Here, we report a case of Cronkhite-Canada syndrome in a patient with schizophrenia. A 64-year-old man, who had been diagnosed as having a schizophrenic disorder at the age of 30, presented with alopecia, atrophic nail changes, hyperpigmentation of the skin, and inflammatory polyposis of the stomach and colon. Endoscopic ultrasonography of the stomach and colon revealed diffuse mucosal thickening with small hypoechoic areas, corresponding to edema of the lamina propria. After treatment with parenteral hyperalimentation and tranexamic acid, his physical findings and polyposis gradually improved. This is the first report of Cronkhite-Canada syndrome in a patient with schizophrenia.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalInternal Medicine
Issue number4
Publication statusPublished - Feb 15 2007

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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