TY - JOUR
T1 - Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol
AU - Ochiai, Takashi
AU - Ohno, Shigekazu
AU - Soeda, Shinji
AU - Tanaka, Hiroyuki
AU - Shoyama, Yukihiro
AU - Shimeno, Hiroshi
N1 - Funding Information:
This work was supported in part by funds from the Central Research Institute of Fukuoka University and from the Advanced Materials Institute of Fukuoka University. Our thanks to Mr Steven Sabotta for reading the manuscript.
PY - 2004/5/13
Y1 - 2004/5/13
N2 - Crocin is a pharmacologically active component of Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 μM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of α-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons.
AB - Crocin is a pharmacologically active component of Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 μM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of α-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons.
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U2 - 10.1016/j.neulet.2004.02.067
DO - 10.1016/j.neulet.2004.02.067
M3 - Article
C2 - 15147781
AN - SCOPUS:2442604428
SN - 0304-3940
VL - 362
SP - 61
EP - 64
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -