Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement

Yoshihiro Matsumoto, Kenji Hiromatsu, Tetsu Sakai, Yasushi Kobayashi, Yuki Kimura, Jun Usami, Toru Shinzato, Kenji Maeda, Yasunobu Yoshikai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Stimulation of T cells through the T cell receptor (TcR) initiate activation pathways, and paradoxically can also result in activation‐induced cell death. Many factors influence a stimulated cell's decision to manifest one or the other. Here we show that co‐stimulation with LFA‐1 plays a key role in the choice between the two fates, differentiating between αβ and γδ T cells. Peripheral γδ T cells but not αβ T cells undergo apoptosis upon co‐cross‐linking of TcR and LFA‐1 in MRL lpr/lpr mice as well as +/+ mice. Our results suggest that apoptosis of γδ T cells is inducible by combined stimuli independent of the Fas‐mediated pathway.

Original languageEnglish
Pages (from-to)2441-2445
Number of pages5
JournalEuropean Journal of Immunology
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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